Game 51: An All-Inclusive Guide to Mastering the Game Game 51 is a popular card game among card enthusiasts because it blends aspects of skill, stdownload app apkrategy, and some luck. Between two and six players can participate in the game, which is usually played with a standard 52-card deck. By laying down cards in particular combinations and forming melds, the goal is to be the first player to reach a predefined score, usually set at 51 points.